How long a patient will be cranky after undergoing craniotomy varies from person to person. This is because not all craniotomies will result in the patient being cranky. Only in the following cases, patients are likely to be cranky. The first, those patients with severe cranial injuries who themselves have frontotemporal lobe cerebral contusions, they are bound to have a course of crankiness after craniotomy. The second type, craniotomy patients with brain hemorrhage in the frontotemporal lobe. The third type is patients who have undergone craniotomy for brain tumors in the frontotemporal lobe. Patients in this category have a postoperative period of irritability that takes about a month. If olanzapine is given aggressively orally, it is likely that the irritability period will pass in about two weeks.