The main treatment option for medication for H. pylori is quadruple therapy, which is a proton pump inhibitor, bismuth, and two antibiotics. What is the reaction to taking medication for H. pylori needs to be discerned according to the specific medication, and commonly includes epigastric fullness, blackened stools, etc. 1. Proton pump inhibitors: commonly used drugs are omeprazole, lansoprazole, rabeprazole and so on. When the patient suppresses acid for too long or as much as possible, it may cause epigastric fullness, loss of appetite and other reactions. 2. Bismuth: Commonly used drugs include bismuth potassium citrate, which will have reactions such as black tongue and black stools. 3. Antibiotics: commonly used drugs are amoxicillin, clarithromycin, metronidazole, etc. These drugs may cause gastrointestinal symptoms, such as nausea, loss of appetite, dysbiosis of the digestive tract and so on. Serious cases can also lead to liver function damage. Combined use of drugs in the process need to be under the guidance of the doctor to take drugs according to the regularity. At the same time, we should pay attention to dietary regulation to reduce the occurrence of adverse reactions, once the symptoms of adverse reactions appear, you need to consult a doctor in time.