Rash caused by erythromycin usually takes about a week to subside. Roxithromycin is a macrolide antibiotic, antibacterial spectrum similar to erythromycin, suitable for the treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis and otitis media caused by sensitive bacteria, and pneumonia caused by Mycoplasma pneumoniae. Rash, itchy skin and other adverse reactions are occasionally seen during the use of the drug, usually subside one week after stopping the drug. The use of Roxithromycin should be carried out under the guidance of medical professionals, the main adverse reactions are abdominal pain, diarrhea, nausea, vomiting and other gastrointestinal reactions, allergic to macrolides is prohibited, liver insufficiency should be used with caution, the use of drugs need to be regularly tested during the liver function. If discomfort occurs, it should be promptly to the hospital, and follow the doctor’s instructions for treatment.