Small invisible spines in the hand can be treated with tweezers, tape or medication. 1. Tweezers: For cases where the end of the thorn is exposed outside the skin, the tweezers can be sterilized under a light and the end of the thorn can be removed by clamping the end of the thorn. 2. Tape: If the tweezers can not be removed, you can choose a sticky tape, stick it on the part of the thorns, and then tear the tape quickly in the direction of the thorns, and then the thorns can be glued out under normal circumstances. 3. Medication: Erythromycin ointment and mupirocin ointment can be used externally to prevent infection. 4. Surgery: when the thorn is stuck in the hand, because it is stuck deep and small in size, it can be surgically incised, and the wound can be closed after the thorn is found and taken out.