High glutamyl transpeptidase and alkaline phosphatase are indicative of liver and biliary disorders. Glutamyl transpeptidase is mainly found in the liver, pancreas, and kidneys. When liver function is damaged, glutamyl transpeptidase will enter the body’s blood serum, and then glutamyl transpeptidase will be elevated. Glutamyl transpeptidase is mostly checked together with alkaline phosphatase. When both are elevated, it indicates liver and biliary disease. Common diseases that can lead to impaired liver function include chronic hepatitis, cirrhosis, fatty liver, and liver cancer. These diseases lead to necrosis of liver cells and impaired liver function, thus affecting the metabolism of glutamyl transpeptidase and alkaline phosphatase and leading to elevations. The bile secreted by the liver is mainly stored in the gallbladder, once the gallbladder is diseased, it will cause the bile to enter the human blood circulation, which will also cause high glutamyl transpeptidase and alkaline phosphatase, such as cholecystitis, gallstones, etc.