Gout medication usually refers to anti-gout medication, gout patients taking anti-gout medication is possible to cause urticaria, which is likely to be related to the adverse reactions of anti-gout medication, which can lead to allergic reactions, resulting in drug urticaria. Antigout drugs can be divided into drugs that inhibit uric acid production, such as allopurinol; drugs that promote uric acid excretion, such as probenecid, thioredoxolone, benzbromarone, etc.; drugs that inhibit granulocyte infiltration, such as colchicine. In addition, certain anti-inflammatory analgesics, such as indomethacin, prednisone, naproxen, etc. can also be used in the treatment of acute gout. Urticaria, also known as rubella, is an edematous reaction due to dilation of small blood vessels in the skin and mucous membranes and an increase in permeability, which usually subsides within 2 to 24 hours, but is prone to recurring new rashes that can last for days to months. The causes of urticaria are complex and most patients have difficulty identifying the cause, especially in chronic urticaria. One of the common factors that can lead to the emergence of urticaria is medications. Gout patients take such as allopurinol, benzbromarone, colchicine, indomethacin and other anti-gout medications have a certain chance of causing allergic reactions, resulting in hives and other rashes, so taking anti-gout medications is likely to cause hives. If the patient takes anti-gout medication hives and other related discomfort, it is recommended to stop taking the drug immediately, and timely medical treatment, follow the doctor’s instructions standardized treatment, and at the same time need to try to avoid taking such drugs, so as not to damage the health. It is recommended to take anti-gout medication under the guidance of a doctor, do not take it without authorization, so as not to cause adverse consequences.