Long-term use of omeprazole has a certain degree of damage to renal function, the drug is a proton pump inhibitor, the final metabolism to be excreted through the kidneys, the renal function is likely to cause a certain degree of damage. As omeprazole will be metabolized in the liver and excreted from the kidneys, it may lead to abnormal renal function; the manifestation of abnormal renal function, there are light and heavy, light is only abnormal in the urine, that is to say, there is an increase in the protein in the urine, and there is an increase in the non-homogeneous red blood cells in the urine. The more serious manifestation of abnormal renal function is mainly the increase of creatinine in blood. Therefore, in the long-term use of omeprazole for the treatment of gastric ulcer, duodenal ulcer people need to carry out regular review of renal function. If renal function impairment occurs, you need to consult a doctor in time and follow the doctor’s instructions.