When venous compression, venous thrombosis and cardiac insufficiency, etc., will lead to the obstruction of venous return in the lower limbs, the osmotic pressure of the tissue interstitial increases, and the fluid accumulates in the tissue interstitials, thus forming the edema of the lower limbs. The general treatments include surgery, anticoagulation, diuretic treatment and so on. 1. Surgical treatment: Multiple venous compression may be caused by occupying lesions such as nearby tumors. When the veins are compressed, blood circulation is obstructed, which can lead to edema. If the lower extremity venous compression causes obstruction of venous return and leads to lower extremity edema, surgical treatment is needed to release the compression, and the edema can mostly subside by itself after surgery. 2. Anticoagulation therapy: Deep vein thrombosis of the lower limbs can lead to narrowing and blockage of venous return, which in turn causes edema of the lower limbs. If the lower extremity venous thrombosis caused by venous return obstruction and lead to lower extremity edema, early thrombosis (within 72 hours) can use heparin, warfarin and other drugs for anticoagulation, thrombolytic therapy. 3. Diuretic treatment: If the edema is caused by the obstruction of venous return due to cardiac insufficiency, diuretic treatment can be carried out by giving cardiac glycosides such as cediran and diuretics such as furosemide, and when the cardiac function improves, the symptoms of lower limb edema will be relieved. If the situation of lower limb edema caused by obstruction of venous return occurs, it is recommended to go to the regular hospital in time, ask the doctor to clarify the cause of the disease, and carry out the corresponding treatment if necessary.