When the body temperature exceeds 39 degrees Celsius or 40 degrees Celsius, symptoms of heat stroke such as sweating shutdown, dizziness and headache, and mental disorders often occur, and respiratory failure can occur within a few hours in severe cases. The causes of the phenomenon of sweating closed: 1, sweating blister syndrome (dyshidrosis), also known as poor sweating, for a blistering disease of the palms of the hands, feet and plantar areas. The disease is similar to the Chinese medicine field snail herpes, such as “medical jinjian, surgical method” records, “the first born in the form of beans, yellow herpes boring swelling, hard pain can not be on the ground, even a number of herpes, thick skin is difficult to break from.” Some people call this disease in the foot earthworms. 2, foot penetrating damage foot penetrating damage (perforating lesion of the foot), also known as foot penetrating ulcers, foot penetrating disease. It is a chronic ulcerative disease that occurs in the foot. It is mostly seen in men between the ages of 30 and 50. It occurs in the vulnerable areas of the foot and plantar, especially at the first and fifth metatarsophalangeal joints, and the root of the foot may also be involved. Initially, the affected area appears as a small patch of keratinous thickening, shaped like a corns or callus, followed by mild redness and swelling, which gradually softens and necroses under the thickened epidermis, forming an ulcer or fistula. The ulcer is funnel-shaped, with a foul odor and thin pus overflow. There is dark red granulation tissue at the base, and the ulcer is surrounded by thickened keratin, and the damage is often isolated. The skin near the affected area often has sweating closure, but localized hyperhidrosis has also been observed. The course of the disease is longer and can recur after healing. 3, the elderly diabetic peripheral neuropathy neuropathy is one of the most common complications of diabetes, its prevalence can reach 7% to 50%, if including a variety of subclinical neuropathy, it can be up to 90%, is an important cause of disability and death in diabetic patients, a serious threat to the health of diabetic patients. Any part of the nervous system (peripheral nerves, spinal cord and brain) can be involved, either singly or in combination, with peripheral neuropathy being the most common. Especially in the elderly, diabetes is the most common cause of peripheral neuropathy. Peripheral neuropathy refers to the persistent disorders of motor neurons, primary sensory neurons, and peripheral autonomic neuronal axons and supporting tissues in the spinal cord and brainstem, and can present with a variety of clinical manifestations. The neuropathology reveals Schwann cell edema, axonal degeneration and segmental demyelination.