A positive hepatitis B two-to-one 45 represents positive e and core antibodies, which indicates that the patient has had hepatitis B infection or is recovering from it. There is also a case where the patient’s surface antigen level is extremely low and undetected, but in either case a hepatitis B virus DNA test is required. If the test result is negative, it means that the patient is not infectious and can be monitored at any time and protected with the hepatitis B vaccine. If the DNA test is positive, it means that the disease is highly infectious and regular monitoring of liver function, hepatitis B tests and hepatitis B virus DNA is required. If liver function is abnormal, liver-protective medication is required.