Stubborn constipation for more than twenty years is mainly intervened through general treatment, medication and surgery, but the specific efficacy varies from person to person, and must be carried out in accordance with the doctor’s instructions. 1. General treatment: it mainly includes reasonable diet, moderate exercise, and establishment of good defecation habits. It is the foundation of the treatment of this disease, and is of great significance in striving for a better long-term prognosis. 2. Drug therapy: commonly used laxatives: including volumetric laxatives (such as polycarbophil calcium), osmotic laxatives (such as lactulose), stimulating laxatives (such as bisacodyl), etc.; gastrointestinal stimulants: such as moxabepril, prucalopride and so on. Enemas and suppositories: e.g., Kesiclofenac, cotrimoxazole suppositories. The specific medication should be individualized according to the symptoms present. 3. Surgical treatment: only applicable to the serious condition, conservative treatment is ineffective, at present the need for surgical treatment is still a minority. However, it should be noted that the therapeutic effects of the above methods are still affected by many factors, such as the individual’s physical condition and compliance, the timing of intervention, the severity of the disease, etc., and the specific efficacy of the treatment may differ from one person to another. In addition, it should also be noted that persistent constipation may have inflammatory bowel disease, hemorrhoids, puborectalis syndrome and other primary diseases, diagnosed on the basis of the above symptomatic treatment, but also need to carry out causative treatment. Intractable constipation lasts for more than twenty years with a longer course, and is generally more difficult to treat. Therefore, the patient must be under the guidance of the doctor according to the actual situation of the choice of treatment program, do not blindly dispose of their own, so as not to cause adverse consequences.