Some newborns with unclosed foramen ovale do not have any symptoms and are only detected during pregnancy or newborn cardiac ultrasound. In severe cases, there are manifestations of cardiac insufficiency, such as dyspnea after oxygen deprivation, blue lips, mental instability, loss of appetite, and so on. The foramen ovale is a physiologic passageway formed by the heart during embryonic development. After birth, along with the initiation of pulmonary respiratory function in newborns, the foramen ovale closes around two months, and completely closes by one year of age. Therefore, non-closure of the foramen ovale in newborns is a common physiologic phenomenon, and most of them do not have any uncomfortable symptoms. However, the foramen ovale that is accompanied by symptoms of severe cardiac insufficiency may be congenital heart disease. The right atrium and right ventricle are found to be enlarged after cardiac ultrasound, resulting in, for example, dyspnea after oxygen deprivation, blue lips, mental instability, loss of appetite, etc. Newborns should be hospitalized as soon as possible. They should be seen in hospital as soon as possible and treated surgically if necessary.