The normative term for small lymphocytic lymphoma of the lymph nodes is small lymphocytic lymphoma, and treatments include chemotherapy, immunosuppressive therapy, and surgery. Small lymphocytic lymphoma is a malignant lymphoma, belongs to non-Hodgkin’s lymphoma and is an inert lymphoma. 1. Chemotherapy: commonly used chemotherapy regimens are CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) and so on. 2. Immunosuppressive therapy: commonly used drugs are cedarbenazine, ibrutinib and so on. Lenalidomide, an immunomodulator, can also be used in combination with chemotherapy. 3. Surgical treatment: splenectomy is feasible for patients with indications of combined hypersplenism. It should be noted that patients with small lymphocytic lymphoma may survive for a long time, and it is recommended that patients establish confidence in treatment and carry out standardized treatment as soon as possible. The above drugs should be used under the guidance of doctors.