Palm lines are very deep touch very rough mainly local treatment, the cause of this situation may be callus, palmoplantar keratosis and so on. 1. Callus: callus is a thickening of the stratum corneum caused by long-term pressure and friction of the skin, generally without treatment, if you can reduce friction can be relieved. Thicker lesions appear pain can be soaked in hot water hands, and then coated with moisturizing cream, you can also use medical gloves or plastic wrap closed local, to be softened after the keratin, under the guidance of the doctor, the use of surgical blades to eliminate the surface of the stratum corneum, but also can be treated with medication, such as salicylic acid cream, and so on. 2. Palmoplantar keratosis: Palmoplantar keratosis is a chromosomal dominant/recessive genetic disease. It can be treated by applying retinoic acid-based medications, such as isotretinoin and tazarotene, or by using keratolytic agents, such as 15% salicylic acid and 20% urea cream. The palm lines are very deep and rough to the touch, and care should be taken to minimize friction on the hands. If you need to use medication to treat it, use it as prescribed by your doctor.