Higher and higher blood pressure in dialysis patients is considered to be related to excessive fluid loading in the body, factors such as nerves and body fluids, and the composition of dialysis fluid, and requires the following treatment options: limiting fluid intake, reducing weight gain during the dialysis period, and enhancing dialysis dehydration; increasing antihypertensive drugs such as valsartan; and adjusting the concentration of sodium ions and calcium ions in the dialysis fluid, etc. to correct the blood pressure. There are many reasons why the blood pressure of dialysis patients is getting higher and higher, such as excessive fluid load in the body, the role of neurological, humoral and other factors, and the effect of dialysis fluid composition on blood pressure. Treatment should avoid excessive weight gain during the dialysis period, increase the number of dialysis sessions, prolong the dialysis time to maximize the amount of ultrafiltration to reach dry weight as soon as possible, and consider continuous renal replacement therapy if necessary; add drugs such as Irbesartan or Benadryl, and adjust the concentration of sodium ions and calcium ions in the dialysis fluid, etc. All of the above drugs should be used according to the doctor’s prescription, and can help to control the blood pressure. All of the above medications should be used as prescribed by the doctor, and should not be self-administered. Dialysis patient’s blood pressure is getting higher and higher, it is recommended to consult a regular hospital, complete the relevant examination under the guidance of the physician, to clarify the cause of the disease, and carry out targeted treatment.