Mycoplasma resistance is usually not a lifelong resistance, and the duration of resistance is usually about 1 month. Drug resistance refers to the pathogen that causes the disease to the drug tolerance, insensitivity, such as bacteria, fungi to antibacterial drugs gradually tolerate, so that the therapeutic effect of antibacterial drugs to reduce or even disappear. If the patient due to mycoplasma infection in a short period of time to take a large number of drugs to kill mycoplasma or take each other to kill mycoplasma drugs will cause drug resistance. However, drug resistance is generally temporary, and when the resistant drug is discontinued for more than 1 month, the mycoplasma will be re-sensitized to the drug that has become resistant. If mycoplasma is resistant to a drug, you can stop taking the drug and do a drug sensitivity test in the hospital to use another sensitive drug. It is recommended that patients who develop drug resistance should consult their doctors in a timely manner and use the drugs in a rational and standardized manner under the doctor’s guidance to avoid the emergence of drug resistance.