I. Treatment 1. Non-pharmacological therapy: Physical and cognitive functions can be improved by the following methods: Somatic exercises to improve the patient’s muscle strength, balance and coordination Active use of the brain to prevent brain decline to cognitive training and memory rehabilitation Regular participation in social activities to maintain contact with the surrounding environment Arranging a regular life and reasonable distribution of rest and activity time Active use of various cues to help patients remember 2. Treatment As with hypertension and diabetes, although patients cannot be cured, medications can control the disease, delay deterioration, and improve quality of life. Therefore, active treatment is necessary. Please don’t mistake it for normal aging and ignore it, and miss the best time for treatment. Although there is no cure for Alzheimer’s disease, there are medications that can help control the disease and delay its deterioration. At the same time, good treatment results require the cooperation of caregivers and long-term, regular daily medication. 1) Cholinesterase inhibitors: The European Dementia Guidelines, the American Psychiatric Institute and the Chinese Dementia and Cognitive Impairment Guidelines all recommend these drugs as first-line medications for mild to moderate Alzheimer’s disease. 2) Excitatory amino acid receptor antagonists: such as meperidine 3) Other drugs such as cerebral metabolizers, cerebral vasodilators, lipid-regulating drugs, etc. Can taking drugs for Alzheimer’s disease improve those symptoms? 1. Ability to perform daily activities: for example, eating, dressing, bathing, brushing teeth, using daily tools (telephone, TV, etc.), and recognizing time. 2. Behavioral and psychological symptoms: for example, apathy, personality changes, irritability, depression, anxiety, delusions, fantasies, and other psycho-behavioral symptoms. 3. Cognitive symptoms: for example, memory loss, poor verbal expression, loss of direction (getting lost), confusion about people, time and space. 3. How do I know that taking anti-dementia medication is effective? Daily records (ability to perform daily activities), BPSD (behavioral and psychological), Cognition (cognition) and other symptoms to assess improvement. IV. What is the dose and duration of medication for Alzheimer’s disease? As with hypertension and diabetes, long-term medication is required to control the condition. As for the dosage, the physician will give the appropriate dosage to patients with different body types. When patients start taking these medications, they must start with the lowest dose and slowly change to a higher dose until the patient experiences side effects and cannot tolerate them, then they can stop taking the higher dose or even return to the lower dose. This method allows the patient’s body to adapt to the drug and reduces the chance of side effects such as nausea. Each person’s tolerance level is different and different doses need to be chosen to achieve maximum effect. For example, for carbaratine, start with 1.5mg-3mg/day and slowly increase the dose to a therapeutic maintenance dose of 6-12mg/day (the dose will be adjusted according to the patient’s gastrointestinal tolerance). Taking such drugs for Alzheimer’s disease may cause side effects such as nausea, vomiting, diarrhea, stomach pain, lack of appetite, dizziness, etc., which may increase with the dose. If symptoms persist or are severe, please inform your physician proactively. Gastrointestinal side effects will decrease with the duration of treatment. Avoid or reduce the occurrence of gastrointestinal side effects: (Take carboplatin as an example) 1. take with food 2. slowly increase the dose 3. increase the number of oral doses (if you have family members to take care of you at home, you can change 2 doses a day to 3 doses a day) 7. advice to caregivers Patients must have someone with them when taking medication to help them take all the medication to avoid forgetting or taking it by mistake. For a patient who refuses to take his medication, be patient and persuasive. Be sure to watch him take the medication, have him open his mouth and watch to see if he swallows it. Please do not assume that the patient can manage the medication on his or her own. Build readings for the caregiver to give the patient only one serving of the current dose at a time, rather than giving the patient the entire packet of medication, and please keep the medication out of the patient’s reach.