Whether creatinine decrease is the recovery of renal function needs to be judged according to the causes. If creatinine decrease is caused by physiological reasons such as malnutrition, or serious systemic diseases such as hyperthyroidism, tumors and other consumptive diseases, this situation is not the recovery of renal function; if creatinine decrease is caused by acute kidney injury after active treatment and correction of reversible factors, it usually indicates that renal function is recovering. Creatinine decrease can be seen in physiological reasons such as malnutrition or low muscle content, but also in severe systemic diseases such as anemia, hyperthyroidism, leukemia, tumors and other wasting diseases. Creatinine decrease in this case is not that the kidney function is recovering. If creatinine is elevated due to acute kidney injury, after timely rehydration, symptomatic supportive treatment and relief of urinary tract obstruction and other factors to correct reversible factors, creatinine may decline, which indicates that renal function is recovering. If patients find abnormal creatinine, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.