Toe numbness generally depends on the condition to decide what medication to take: if the toe numbness is a peripheral nerve compression symptom, you can generally consider taking methylcobalamin capsules to relieve the nerve numbness symptoms, and then to conduct a pathogenic retrospective examination to consider whether there is cervical spondylosis or lumbar spondylosis. Numbness of the toes caused by cervical spondylosis is usually a feeling of stepping on cotton in the feet as well as weakness of both lower limbs, accompanied by a feeling of binding in the chest. If the numbness of the toes is caused by the lumbar spine, there is generally limited flexion and extension of the big toe and positive straight leg raise test of both lower extremities, so symptomatic treatment should be carried out according to the specific condition, and do not take drugs blindly to avoid delaying the condition.