The treatment of lesbianism is a major concern for the patient’s family. Internationally, homosexuality is not considered a disease and there is no way to talk about its treatment, and marriage between homosexuals is internationally allowed. The treatment of lesbians is more about the intervention of negative emotions, because this group of people is under more pressure from family and society than normal people, so often combined with more obvious negative emotions. If the negative emotions cannot be resolved through psychotherapy, medication can be used if necessary to reduce the impact of the negative emotions on their study, work and life. In clinical practice, the most used drugs include sertraline, escitalopram, citalopram, venlafaxine, duloxetine, etc. Also, lesbians should be instructed to handle gender relations correctly and avoid the effects of sexually transmitted diseases on their bodies.