Liver spots on the face are also called chloasma. There is no significant and effective way to treat melasma. The following treatment options are provided:1. Avoid sunlight exposure, oral contraceptives, and the application of photosensitizing drugs and scented cosmetics. Oral vitamins C and E, carotene, fish oil, etc. can play a role in defense against ultraviolet radiation, and external sunscreen should be insisted on. 2. Topical glucocorticoids, medium-acting hormone 0.1% hydrocortisone butyrate cream, can be used to treat melasma with less adverse reactions. 3. Topical retinoids, such as 0.1% all-trans retinoic acid cream, can be used once a day. 4. Depigmentation agents, topical 20% azelaic acid cream or 2% hydroquinone cream, etc. 5. Chemical peeling, for dermal melasma treatment, 50%-95% phenol or 10%-50% trichloroacetic acid solution can be used. 6. Q-modulated laser and pulsed dye laser can be applied for removing melanin particles in the dermis with certain effect.