Spironolactone tablets can be replaced. Spironolactone tablets belong to potassium-preserving diuretics, but the side effects are large, the stimulation of the gastrointestinal tract can cause diarrhea, vomiting and other adverse reactions, long-term use of the drug may also lead to male impotence, breast development, sexual function hypogonadism, female breast distension and pain, hair growth, voice coarseness and so on; can be used with potassium-preserving diuretics amphotericin or amiloride hydrochloride instead. 1. Amphotericin: It can inhibit the reabsorption of sodium ions in the distal tubules and collecting ducts of the kidneys and reduce the secretion of potassium ions. It has a rapid onset of action but weak diuretic effect, and is usually used in combination with potassium-excreting diuretics for the treatment of various edematous diseases. The main adverse reactions include hyperkalemia, abdominal pain and diarrhea, headache and dizziness. It is contraindicated in patients who are allergic to drug components, patients with hyperkalemia and patients with severe hepatic or renal insufficiency. 2. Amiloride Hydrochloride: It acts on the distal tubule of kidney, which can block sodium-potassium exchange, promote the excretion of sodium ions and chloride ions and reduce the secretion of hydrogen ions and potassium ions. It is used as an adjunctive therapy in the treatment of edematous disorders and intractable hypokalemia. The main adverse reactions include hyperkalemia, hypercalcemia, hyponatremia, nausea and vomiting, abdominal distension, dizziness and headache, chest tightness. Contraindicated in patients with hyperkalemia, patients with severe renal decompensation. When using potassium-preserving diuretics, be sure to use the drug under the guidance of a specialist, and pay attention to monitoring blood electrolyte levels to avoid serious adverse effects.