High transaminase after choledochal cyst surgery, need to consider liver damage, or postoperative infection, can be treated with hepatoprotective drugs, if you consider postoperative infection need to use anti-infection treatment. The main treatment of liver damage is based on liver-protecting drug therapy, with less inflammation can be tried silymarin, and more severe inflammation can be tried glycyrrhizic acid preparation, which can play an anti-hepatic inflammation role by inhibiting the activity of phospholipase A2, such as diammonium glycyrrhizinate, or glycyrrhizic acid monoammonium cysteine complex preparation, which can also play a role in neutralizing the reactive oxidants. Other commonly used drugs such as reduced glutathione. Ursodeoxycholic acid may be used in case of cholestatic type. Biliary surgery is a potentially infectious surgery, patients may be at risk of postoperative infections, transaminase elevation can also be seen in biliary infections, in the use of the above hepatoprotective drug therapy, anti-infective treatment is also needed, recommended the use of cephalosporin III antibiotics, which have a strong bactericidal effect on gram-negative bacilli, commonly used ceftriaxone, cefoperazone and so on. High transaminases after choledochal cyst surgery should be further examined to clarify the etiology and actively treated.