Natural progesterone refers to progesterone not normally secreted by human body, but outside plant-derived or synthetic progesterone, which is progesterone mainly secreted by ovaries and usually exerts its effect on the basis of estrogen action. It can inhibit uterine contraction and play the role of fetal preservation; it can also transform the proliferative endometrium into the secretory phase, which is conducive to the fertilization of eggs; it can also promote the development of mammary gland follicles, accelerate the shedding of vaginal epithelium, promote water and sodium excretion, and raise the basal body temperature. Therefore, if the level of progesterone in the body is low, menstrual disorders, infertility or recurrent miscarriage may occur. If the amount of progesterone secreted by the ovaries is not enough, it is necessary to supplement exogenous natural progesterone to maintain normal physiological functions, and the commonly used ones are dydrogesterone tablets, progesterone gel pills, progesterone injections and methylhydroxyprogesterone, etc. However, the sex hormone six items should be checked before use and the medication should be used reasonably according to the results.