Whether taking doxycycline hydrochloride tablets can be vaccinated with the new crown vaccine mainly depends on the individual’s condition, if one is taking doxycycline hydrochloride tablets due to an acute illness, one cannot be vaccinated with the new crown vaccine; however, if the individual’s condition is stable and in the recovery stage, and there is no obvious discomfort, the new crown vaccine can generally be vaccinated. Doxycycline Hydrochloride Tablets is a tetracycline antibiotic drug that can be used to treat a variety of infectious diseases caused by sensitive bacteria, such as rickettsial disease, mycoplasma infections, chlamydia infections, regression fever, cholera, bubonic plague, soft chancre and so on. New Crown Vaccine is a vaccine to prevent New Crown Pneumonia. Whether or not the vaccine can be inoculated depends on the individual’s physical condition, if one is in the acute infection stage, one cannot be inoculated with the vaccine, and needs to wait until the body is cured; if one’s condition has been stabilized, and there is no fever or other abnormal symptoms of discomfort, one can be inoculated with the vaccine normally. The use of doxycycline hydrochloride tablets may cause nausea, vomiting, abdominal pain, diarrhea, hepatotoxicity, maculopapular rash and other adverse reactions. The drug needs to be contraindicated in individuals who are allergic to tetracyclines. Individuals need to stop using the drug and treat any secondary infection that occurs while using the drug. Individuals taking this medication should be evaluated by a physician to determine if they can receive New Crown Vaccine. Note: In this article, the terms “neocoronavirus pneumonia and novel coronavirus pneumonia” were renamed to “novel coronavirus infection” on December 26, 2022, as announced by the National Health Commission.