Whether or not topical medications hurt the liver and kidneys depends on the nature of the medication, for example, lead pills, red powder, etc. can hurt the liver and kidneys if used inappropriately, and it is recommended that the medication be used under the guidance of a doctor. Lead Dan is processed from pure lead oxide, can be used externally to pull out poisonous muscle, this product is toxic, improper use can cause lead poisoning, it is advisable to use with caution, and can not be used continuously in order to prevent accumulation of poisoning. Red powder is made of mercury, fire nitrate, alum sublimation of red mercuric oxide, there is a big poison, with the role of pulling out the poison to get rid of corrosion of the muscle, can only be used externally, can not be taken internally. Long-term large quantities, large areas can lead to mercury poisoning, and even liver and kidney function damage. Other drugs that can be used externally, such as Zihuadidin, can be used externally to clear heat and detoxify the body (to remove heat and toxicity in the body), but generally does not have a detrimental effect on the liver and kidneys, so whether the external use of drugs to harm the liver and kidneys, need to be combined with the nature of the drug to decide. It is recommended to ask your doctor before using topical medications, and use them in a standardized way under your doctor’s guidance.