Major syndrome is relatively serious. The disease itself is not life-threatening, but it can cause complications.
Major manifestations of Major’s syndrome are blepharospasm and oral-mandibular dystonia, involving the eye muscles and the muscles of the mouth and jaw.
Involvement of the ophthalmic muscles is characterized by eyelid irritation, dryness of the eyes, photophobia, and frequent eye transients, which progress to involuntary eyelid closure. Severe cases can lead to functional “blindness”. Blepharospasm is often exacerbated by nervousness, bright light exposure, reading, and staring, and is alleviated by speaking, singing, opening the mouth, chewing, and laughing, and disappears during sleep.
Mouth and jaw muscle involvement is manifested as opening and closing the mouth, skimming, grinning, shrinking the lips, stretching and twisting the tongue, coveting and clenching the teeth. In severe cases, the jaw can be dislocated, teeth worn to the point of falling out, tearing the gums, biting off the tongue and lower lip, affecting vocalization and swallowing. Spasms are often triggered by speaking and chewing, and can be relieved by touching the jaw and pressing on the lower frontal area, and disappear during sleep.
Patients in the disease generally does not affect the patient’s life safety, but will affect the normal work and life, the patient itself has a greater impact, and is prone to cause other complications, such as facial muscle spasms, and functional “blindness” may lead to traffic and other accidents to form a certain degree of trauma.
In the treatment of Meijer syndrome, first need to carry out relevant examinations, such as cranial CT, magnetic resonance, etc., to rule out whether there is intracranial lesions. Then according to the results of the examination targeted treatment, do not blindly use drugs, so as not to lead to aggravation of the condition.