Cotrimoxazole and clarithromycin can be used together. Cotrimoxazole is a combination drug that can be used to treat wheezing bronchitis, bronchial asthma, and other respiratory disorders that cause coughing, wheezing, and coughing. And clarithromycin is a kind of macrolide antibiotic drug, against gram-positive bacteria, some gram-negative bacteria, mycoplasma and so on. It can exert an inhibitory effect and can be used to treat infectious diseases caused by sensitive bacteria. There is no contraindication between Fosfomycin and Clarithromycin, it can be used in combination to deal with related diseases. Adverse reactions such as rash, itching, nausea, vomiting, dizziness, loss of appetite, difficulty in urination, etc. are occasionally seen with the use of Compound Methoxonamine, which usually disappears after stopping the drug. The major adverse reactions caused by clarithromycin, include oral odor, gastrointestinal reactions, headache, and transient elevation of serum aminotransferase. Cotrimoxazole needs to be contraindicated in breastfeeding women, people who are allergic to the ingredients contained in the drug, people with severe cardiovascular disease in asthmatic crisis, infants and children under the age of eight years. Clarithromycin is contraindicated in people who are allergic to macrolides, pregnant women, breastfeeding women, people with severe hepatic impairment, people taking terfenadine for treatment, people with water-electrolyte disorders. After taking cotrimoxazole, if an adverse reaction occurs, stop taking the drug and seek medical help. People with severe renal impairment need to follow the doctor’s advice on the dosage of Clarithromycin to make reasonable adjustments. To strictly follow the doctor’s instructions to regulate the use of cotrimoxazole and clarithromycin, not to abuse the drug.