The current eradication rate of H. pylori is 50%-80%, and an effective H. pylori eradication situation should be more than 80% for better results. But because of the current national antibiotic abuse and high resistance rates, many antibiotics are not ideal for bactericidal effects, such as metronidazole and clarithromycin and levofloxacin, the Chinese have high resistance rates, which can even be as high as about 50%, and the resistance rate of metronidazole can even reach 70% in some areas. So if antibiotics are chosen for these insensitive antibiotics, such as metronidazole, levofloxacin and clarithromycin, it means that the bactericidal rate will be lower. The antibiotics that are sensitive to kill H. pylori are amoxicillin and tetracycline, which are the two more sensitive antibiotics. Therefore, for the current situation because the eradication rate of H. pylori is not ideal, the first to ensure that patients try to choose sensitive antibiotics, the second in the process of sterilization must be combined with the use of bismuth preparations, the choice of PPI preparations for less metabolic impact, can effectively improve the cure rate of the joint killing of H. pylori.