Levodopa is the drug of choice for Parkinson’s disease medication, the effect of the drug is very obvious in the initial period, but some patients are too afraid of the side effects of levodopa. Some patients are afraid to take levodopa because they are worried about the toxicity of levodopa to the liver and kidneys. Levodopa is the “gold standard” for Parkinson’s disease. Although it is not the perfect choice, it is the most effective drug available. These side effects of levodopa can be reduced or delayed with appropriate treatment. What are the side effects of levodopa? Recent side effects: 1, gastrointestinal reactions: mainly manifested as nausea, vomiting, anorexia and constipation. The appearance of these symptoms has a clear dose-dependence, the higher the dose, the more obvious side effects. Therefore, when you first start taking levodopa drugs, you should start with a small dose and increase the dose slowly and gradually, or don’t take too large a dose each time and increase the number of times you take it. 2, cardiovascular side effects: such as upright hypotension, arrhythmia. Upright hypotension is characterized by dizziness when changing position, such as when standing up from a sitting position. It usually occurs in patients who have just started to take levodopa drugs, and mostly disappears after a few weeks and months. A small number of patients can appear panic, tachycardia symptoms, serious cases should be discontinued. 3, sleep disorders and psychiatric symptoms: some patients may experience increased sleep or insomnia, but most do not affect the treatment. A small number of patients appear mild mental confusion 1 hour after taking the drug. A few other patients experience serious mental symptoms, anxiety, delusions, hallucinations and so on. This phenomenon often occurs after dusk, and these symptoms can be alleviated and disappear after reducing the levodopa dose or discontinuing the drug. Distant side effects: Distant side effects are mostly seen after 2-5 years of taking the drug: 1, anisocoria: i.e., the patient develops involuntary abnormal movements, which are manifested as involuntary twitching of the head and face, pouting of the mouth, turning of the tongue in the mouth, and shrugging of the shoulders and purposeless movements of the limbs. 2, motor fluctuations: one is the end-of-dose phenomenon, manifested as a shortening of the effective time after each dose of medication, and aggravation of the symptoms of Parkinson’s disease in the stage before the next dose. This phenomenon is predictable. Another is the “on-off” phenomenon. Mostly in the drug several years after the unpredictable “on” and “off”. 3.Morning stiffness: It is manifested as the aggravation of symptoms in the morning when getting up, and the difficulty of activity. Exercise can be strengthened and practiced consistently to relieve morning stiffness. 4, delayed onset of effect: manifested as a prolonged period of time after taking the drug, often associated with gastric emptying obstacles and the impact of diet. Diet can be adjusted to improve, gastric emptying obstacles need to consult a physician targeted treatment.