LDL 5.29mmol/L requires treatment, including lifestyle intervention and medication. 1. Lifestyle intervention: low-salt, low-fat diet, appropriate exercise, increase energy expenditure, maintain a healthy body weight, quit smoking and drinking. 2. Drug therapy: The drugs for LDL elevation treatment mainly include statins, bile acid sequestering agents, intestinal CH absorption inhibitors, Probucol, etc. (1) Statins: such as atorvastatin, resuvastatin, etc., these drugs have liver damage, rhabdomyolysis, creatine kinase elevation and other side effects, the use of liver function and creatine kinase need to be monitored, etc., these drugs and other lipid-lowering drugs can be combined to enhance the side effects of the drug should be used with caution, children, pregnant women and women preparing to give birth to a child should not be used. (2) bile acid chelator: such as kauleidenamine, etc., the main side effects of nausea, vomiting, abdominal distension, abdominal pain, constipation, etc., this kind of drugs can interfere with the absorption of folic acid, statins, beta drugs, etc., need to pay attention to the use of drugs. (3) Intestinal CH absorption inhibitors: such as ezetimibe, common side effects include gastrointestinal reactions, headache, muscle aches and pains, and elevated aminotransferases, etc., and attention should be paid to monitoring liver function and creatine kinase. (4) Probucol: common side effect is nausea, the most serious adverse reaction is to cause ECG QT interval prolongation, so arrhythmia, QT interval prolongation of people prohibited this drug. Low-density lipoprotein 5.29mmol / L, should be as early as possible to the hospital, identify the cause of the disease and comply with the doctor’s instructions targeted treatment, avoid blind use of drugs, so as not to delay the condition.