Whether intrahepatic bile duct stones are serious or not cannot be generalized, but should be analyzed on a case-by-case basis, mainly based on the size and number of stones, the patient’s clinical manifestations and the presence or absence of structural lesions in the liver. It is recommended to visit the hospital in time and follow the doctor’s instructions for treatment. When the stones are relatively small and few in number, they usually do not cause obvious clinical symptoms, and the structure of the liver does not change, at this time the condition is relatively mild and not serious. The condition is mild and not serious. It can be left untreated with better observation and follow-up. If the stones are larger and more frequent, and also cause obvious clinical symptoms, such as abdominal pain, fever, jaundice, and the liver has obvious lesions, such as liver suppuration and necrosis, liver atrophy and sclerosis, etc., then the condition will be more serious, and need to be treated in time. It is recommended to consult the doctor in time, improve the examination, and carry out treatment under the guidance of the doctor.