Due to the difference in severity and speed of development of chronic kidney disease, its development to the stage of renal failure varies from 5 to 6 years or 20 to 30 years. However, if the treatment is not timely, the ultimate danger is not uremia. Of course, different patients with uremia have different symptoms, but when the following symptoms appear in the body, you should go to the hospital in time for early diagnosis and early treatment. 1, poor appetite, taste disorder and nausea and vomiting, diarrhea, abdominal distension and constipation. 2.White or yellow face. 3, swelling. 4.Decreased or increased urine output. 5.High blood pressure, and frequent nose bleeding, gum bleeding. 6, easy fatigue, weakness, especially in daily life is very busy green people, fatigue is often a common occurrence, it is easy to be ignored.