Severe iron deficiency anemia requires blood transfusion therapy, iron supplementation therapy, as well as finding the cause of iron deficiency and treating the cause. 1. Patients with severe iron deficiency anemia often have symptoms such as dizziness, fatigue, panic, chest tightness, shortness of breath, etc. because of severe anemia, and need blood transfusion supportive treatment, such as suspension red blood cell transfusion. 2. For patients with severe iron-deficiency anemia, iron supplementation therapy is recommended as intramuscular iron supplementation, or intravenous iron supplementation, which can rapidly replenish iron, while oral iron supplementation is relatively slow, and iron supplementation through diet is even slower. Drugs include iron sucrose, etc. 3. The most important treatment for iron deficiency anemia is to identify the cause of iron deficiency and remove the causative factors, otherwise the cause of iron deficiency persists and iron deficiency anemia cannot be cured. For example, patients with chronic gastrointestinal bleeding can be examined by gastroenteroscopy to observe the cause of bleeding and be treated with targeted drugs such as omeprazole and growth inhibitors. Specific medication should be under the guidance of a physician.