Wake up every morning hand numbness may be related to physiological factors, but also disease-related factors, physiological factors are mostly seen in the sleep position is not correct, resulting in poor blood circulation, pathological factors are considered cervical spondylosis, carpal tunnel syndrome, peripheral neuropathy, and so on. 1. Physiological factors: waking up every morning with numbness in the hands may be due to incorrect sleeping posture leading to mechanical compression of the arm, resulting in poor blood flow, which is a normal physiological phenomenon, generally without special treatment. 2. Pathologic factors: (1) cervical spondylosis: this is a more common disease causing hand numbness, mainly due to cervical disc herniation may compress the patient’s nerve root. (2) carpal tunnel syndrome: carpal tunnel syndrome is due to the median nerve in the carpal tunnel pressure, and caused by hand numbness and pain, if the patient suffers from carpal tunnel syndrome, may appear every morning waking up numbness of the hand. (3) Peripheral neuropathy: this is a common complication of diabetes, peripheral neuropathy when involving the nerves of the hand, arm and other parts of the hand, may appear in the morning after waking up hand numbness symptoms. Every morning after getting up after the symptoms of numbness, to pay attention, if the symptoms continue to not relieve, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor, improve the relevant examination, to clarify the specific causes of the disease, targeted treatment.