Only the scrotum around the thigh root itching may be a manifestation of diabetes, should also improve the fasting blood glucose, postprandial 2 hours of blood glucose, glycated hemoglobin and other related tests to clarify the diagnosis; may also be caused by skin diseases, infections and other reasons. Diabetic patients with high blood glucose and low immunity are prone to local pathogenic infections, or peripheral nerve sensory abnormalities, prone to itchy symptoms at the base of the thighs. It is recommended to improve the fasting blood glucose, postprandial 2-hour blood glucose, glycated hemoglobin and other related tests to clarify the diagnosis. In addition to diabetes, mycobacterial infections, candida infections, eczema, neurodermatitis and other diseases may also be manifested as itching at the thigh root. The appearance of skin lesions should be timely medical observation, under the guidance of clinicians to regulate the treatment, to avoid causing delays in the condition.