Advanced cholangiocarcinoma may only have a few months of survival time without surgery, but if patients actively cooperate with treatment, the life span of patients can be prolonged. Patients with advanced cholangiocarcinoma need to use comprehensive treatment modalities such as chemotherapy, radiotherapy, targeted therapy and interventional therapy with the help of doctors as soon as possible in order to improve the quality of life of patients and prolong their survival period to the greatest extent. After comprehensive treatment, if the scope of the tumor is reduced, cholangiocarcinoma surgery can be obtained, so that the survival period of patients can be improved with a high probability. Patients should establish confidence in treatment, avoid emotional excitement, keep peace of mind, and adopt a positive mindset to improve patients’ quality of life and prolong their survival time through standardized comprehensive treatment.