Dryness refers to a group of clinical manifestations that manifest as dryness of the mouth and eyes. It can be caused by a variety of reasons, such as drugs, environment, mental stress, and some glandular diseases other than dry syndrome, such as: parotid tumor after facial radiotherapy, etc. Dry syndrome, on the other hand, is a diffuse connective tissue disease characterized by invasion of lacrimal gland, salivary gland and other exocrine glands with lymphocyte infiltration and specific autoantibodies. The etiology and pathogenesis of dry syndrome are still unclear, and the clinical manifestations are relatively complex. The symptoms of oral cavity are mainly dry mouth and swallowing of dry food with the help of water. Frosty sensation in the eyes. Systemic symptoms include dryness of the skin mucosa and purpura-like rash that does not fade when pressed. About 80% of patients present with joint pain. About half of the patients have renal damage with kidney stones, calcification, to hypokalemia due to tubular toxicity. Respiratory system involvement manifests as bronchitis, interstitial fibrosis of the lungs dry pharyngitis. In addition, the nervous system, digestive system and hematological system can be involved. Dry syndrome cannot be cured yet, patients should stop smoking and avoid drinking alcohol. Try to avoid taking drugs like atropine. Treatment is mainly alternative and symptomatic, and the prognosis is better in mild cases. For certain patients with organ damage glucocorticoids and immunosuppressive therapy are needed If left untreated, the condition may deteriorate and even become life-threatening. Therefore, it is important to pay attention to the above symptoms and go to the hospital for examination and treatment in time to avoid delaying the disease.