Blisters or macules are one of the clinical manifestations of erythema multiforme exudative. Erythema multiforme, also known as exudative erythema multiforme, is an acute inflammatory skin disease with a complex etiology. It is also a rare hereditary skin disease associated with genetic mutations and intrauterine infections, with an incidence of less than one in 10,000 cases. Children with this condition are unable to synthesize the structural proteins needed for the epidermis, lack the elasticity and toughness of normal skin, and may develop blisters over a wide area of the body or loose skin when subjected to light friction or touch. The term “epidermolysis bullosa” (EB) was first coined by Koebner in the late 1800s to describe a blistering dermatosis that did not leave a scar. It was subsequently used to describe a group of polygenic dermatoses characterized by susceptibility of the skin and mucous membranes to mechanical injury and the formation of large blisters, as a group of disorders typically affecting the basement membrane area of the skin. Internal organs may also be involved. Clinically, the disease shows great variability. Genetic heterozygosity is also evident, with autosomal dominant and recessive inheritance. Abnormal wound repair can lead to chronic damage and crusting, and metastatic cancer is common. Currently, significant progress has been made in the study of this disease, mainly through molecular cloning encoding some key protein networks that maintain the structural integrity of the skin hierarchy. This disease also belongs to the category of “pemphigus” in Chinese medicine.