Taking chemotherapy drugs may cause kidney injury, patients under the guidance of the doctor reasonable use of drugs. Chemotherapy, as one of the important means of cancer treatment at present, has toxic side effects on normal cells in addition to killing tumor cells. There can be myelosuppression, gastrointestinal reactions, heart, liver and kidney toxicity, decreased immune function, hair loss and other immediate side effects, as well as reproductive toxicity, second tumors and other long-term side effects. Some chemotherapeutic drugs have nephrotoxicity, which can cause kidney injury, mostly manifested as acute necrosis of renal tubular epithelial cells, degeneration, interstitial edema and tubular dilatation, etc., and in severe cases, renal failure can also be induced. Patients should choose reasonable chemotherapeutic drugs according to pathological diagnosis and stage, sensitivity of pharmacological cells to chemotherapeutic drugs under doctor’s guidance. Patients can also add chemotherapy sensitizing drugs and drugs to prevent chemotherapy side effects, such as anti-allergy drugs and anti-emetics, into the chemotherapy drugs according to the doctor’s instructions. It is recommended that patients take chemotherapy drugs in strict accordance with the doctor’s instructions after a reasonable assessment by the doctor, and pay more attention to their own symptoms, and actively cooperate with the doctor to take countermeasures if abnormalities occur.