A positive vaginal discharge for leukocyte esterase indicates that the patient may have vaginal inflammation. Leukocyte esterase is an enzyme contained in leukocytes, which is released by leukocytes when there is localized inflammation in the body to eliminate the inflammation. Therefore, a positive test for this enzyme is commonly used in clinical vaginal discharge to indirectly reflect the presence of leukocytes in the discharge, suggesting that vaginitis may be present. In order to further clarify whether vaginitis is present, it is necessary to check the type of pathogens in the secretion, and also to combine the presence of vulvar itching, abnormal color and odor of the secretion with gynecological examination and vaginal examination to make a comprehensive interpretation. To sum up, it is recommended to consult a doctor for further examination and receive standardized diagnosis and treatment as soon as possible.