Low glycated albumin is due to the following reasons: i. Decreased albumin synthesis. Glycated albumin is the product of glucose binding to serum proteins in the body and mainly reflects the overall level of glycated serum proteins. Low glycated albumin due to reduced albumin synthesis is commonly associated with inadequate protein intake, malnutrition, and wasting diseases. The liver is an important organ for synthesizing various types of proteins, and reduced liver function can directly lead to low glycated albumin. Excessive albumin loss. This condition is common in kidney diseases such as renal insufficiency and nephrotic syndrome. Kidney diseases increase the permeability of albumin, which leads to the loss of albumin with urine and eventually low glycated albumin content in the body. In addition, glycated albumin mainly reflects the body’s blood glucose level within 14-21 days, but it does not have special significance for the diagnosis of diabetes.