Genetic test TT+ indicates low enzyme activity, and the patient has a serious disorder of folic acid metabolism. Genetic testing is generally in the pregnancy test, cardiology, oncology, reproductive center, neurology test more, mainly to detect the metabolism of folic acid reductase enzyme; genetic test TT indicates that the enzyme activity of 30%, genetic test TT + indicates that the enzyme activity is even lower; if the enzyme activity changes, it will lead to a serious impediment to the metabolism of folate, which can easily lead to folate deficiency in the body of the patient. Folic acid deficiency leads to congenital heart disease, neural tube development malformation, cleft lip and palate, etc.; pregnant mothers will develop gestational hypertension, gestational megaloblastic anemia and other diseases. It is recommended that patients need to actively supplement folic acid to prevent adverse outcomes, keep the body under observation, and seek immediate medical attention if they feel unwell.