Gout can be caused by primary factors such as enzyme and metabolic defects, and secondary factors such as diseases and drugs.
1. Primary factors: some of the primary factors leading to gout have not been fully clarified, mainly due to unexplained excess uric acid production or reduced excretion, in addition to hypoxanthine guanine phosphoribosyltransferase, phosphoribosylpyrophosphate synthetase and other enzymes and metabolic deficiencies can also lead to excessive production of uric acid and thus cause gout.
2. Secondary factors: secondary factors leading to gout mainly include kidney disease, blood system diseases (such as acute and chronic leukemia, lymphoma, etc.), drug factors and excessive production of organic acids, which can lead to impaired excretion of uric acid, drugs include tobacco acid, tacrolimus, low-dose aspirin and so on.
Gout patients can go to the regular hospital orthopedics, rheumatology and immunology and other related departments for detailed consultation, and follow the doctor’s instructions for standardized treatment.