The price of Donafenib is affected by drug retailers, health insurance reimbursement amount and other factors, the price varies, the reference price is about 2592 yuan a box. The drug specification of Donafenib is 0.1g*40 tablets/box, and the price is about 2592 yuan a box. The drug has now entered the medical insurance, and the cost can be further reduced if patients are within the medical insurance reimbursement of Donafenib. However, due to different health insurance reimbursement amounts and rates in different cities, patients usually need to pay about RMB 400~600 per box out-of-pocket. This product is mainly used for patients with unresectable hepatocellular carcinoma who have not received systemic systemic treatment. The common adverse reactions of this product include diarrhea, hand and foot skin reactions, decreased platelet count, increased aspartate aminotransferase, hypertension, alopecia, rash and proteinuria, etc. This product is contraindicated in those who are allergic to this product. Please use the drug under the guidance of a physician, if discomfort occurs after use, please consult a physician.