Clean panties without discharge may be a normal physiological factor, or it may be a pathological factor such as premature ovarian failure, resulting in low leucorrhea secretion. No leukorrhea residue in the panties should be judged according to the accompanying symptoms as well as the examination to determine if it is caused by disease.1. Physiological factors: Some women’s vaginal secretions, i.e. leukorrhea amount is originally not very much, so no obvious leukorrhea residue will be seen on the panties. Within 1 week after the menstruation is clean, usually the amount of leucorrhea will also be very small, which is normal. The low estrogen level in menopausal women will lead to a decrease in secretions, which is also a normal physiological phenomenon. 2. Pathological factors: If a young woman who has not yet reached menopause has a sudden decrease in secretions and no obvious leucorrhea during ovulation, consider this as premature ovarian failure. In general, patients may also have hot flashes and night sweats, osteoporosis and other problems. In this case, the patient can undergo relevant sex hormone examination and bone density examination, and if necessary, appropriate sex hormone supplementation to relieve the symptoms.