Leflunomide is effective in the treatment of rheumatoid arthritis and is one of the first-line medications for the treatment of rheumatoid arthritis. Leflunomide belongs to a synthetic immunosuppressant. From a pharmacological point of view, Leflunomide can directly inhibit the proliferation of lymphocytes by inhibiting the biosynthesis of pyrimidine, thus playing an anti-rheumatic role. Therefore, the effect of Leflunomide in treating rheumatoid arthritis is relatively good, which can effectively relieve discomfort and improve the condition. Some patients may experience adverse reactions such as diarrhea, alopecia, fatigue and abdominal pain during the use of the drug. Secondly, the use of Leflunomide is prohibited for pregnant women, lactating women, people who are allergic to the ingredients of this product and people with severe liver damage. Regular monitoring of blood count, liver and kidney function is required during use. Other common drugs used to treat rheumatoid arthritis include methotrexate, salazosulfapyridine and hydroxychloroquine. All of the above drugs should be used in accordance with medical advice. It is recommended that patients should go to the rheumatology and immunology department of regular hospitals for consultation, and choose the appropriate treatment plan under the guidance of doctors, taking into account the characteristics of their own conditions.