Lymphoma grade 4 should be stage IV, it should be treated immediately in regular hospitals, and through reasonable and standardized chemotherapy, it is possible to prolong the survival period. From the clinical analysis, stage 4 lymphoma means that there are single or multiple extra-nodal organs invaded, and there may also be liver or bone marrow involvement. However, stage 4 lymphoma does not mean that it is incurable, most of the lymphomas are very sensitive to chemotherapy, and through scientific and standardized chemotherapy, most of the lymphomas can prolong the survival period, reduce the uncomfortable symptoms of the body and improve the quality of life. In conclusion, if diagnosed with stage 4 lymphoma, patients should go to regular hospitals for scientific and standardized treatment as early as possible, and they also need to build up confidence and actively cooperate with each other to prolong the survival period as much as possible.