Hand and foot pustulosis, or palmoplantar pustulosis, is usually not treated with intravenous drips, but mainly with topical or oral medications, or physical therapy. Palmoplantar pustulosis is a skin disease characterized by erythema, hyperkeratosis, and pustules that occurs in palm and plantar areas such as palms and feet, and belongs to a kind of aseptic pustules. It is mostly treated with topical and oral medications. Topical glucocorticosteroids are the main drugs used in the treatment of palmoplantar pustulosis, including halometasone, mometasone furoate, and compound flumethasone. Calcipotriol ointment, tacalcitol, and retinoic acid ointment are also used for treatment. Commonly used oral medications include avitamin A, cyclosporine, and methotrexate. The presence of palmoplantar pustulosis should be treated promptly, and all medications should be used under the guidance of a medical professional.