Minimally invasive surgery for pituitary tumors can still be painful the next day. Normally the headache will gradually get better and disappear after 3-5 days of minimally invasive surgery for pituitary tumor, so you will still feel pain the next day. The specific reasons may be related to the following situations. 1. On the second day after surgery, the damage to the nasal mucosa cannot heal and there will be obvious pain at the wound. 2. Usually, the next day after minimally invasive surgery for pituitary tumor, the nasal cavity is still filled with swelling sponge for compression and hemostasis. When there is obvious swelling and filling in the nasal cavity, it will cause headache. 3. On the second day after surgery, headache may be felt due to cerebrospinal fluid leakage and low cranial pressure. If intracranial hemorrhage is caused by poor hemostasis in the surgical area, the patient will have headache, vomiting, and in severe cases, even have consciousness disorder. It is usually normal to feel pain on the second day after minimally invasive surgery for pituitary tumor, but if the headache worsens significantly or is accompanied by deterioration of consciousness, it is necessary to report to the doctor in time for relevant examination and treatment.